Experience in determining the individual characteristic frequency (IHF) of the patient, as a screening method for identifying risk groups for the incidence of tuberculosis in the population
AUTHORS : Klimenko P.D. | Palamarchuk M.I. | Klimenko D.P.
RELEVANT UNIVERSITIES : Grodno State Medical University, Regional Clinical Hospital, Grodno, Belarus
The problem of tuberculosis has recently become increasingly important in Belarus due to the unfavorable epidemiological situation. So, over the past ten years, the incidence has increased by 1.8 times, mortality by 1.6 times, morbidity by 1.3 times . Diagnosis of tuberculosis, especially early, identification of risk groups of persons prone to this disease is a promising way to fight tuberculosis.
The currently existing methods for diagnosing tuberculosis have a number of disadvantages, such as: – the duration of obtaining the results (4–6 weeks), the complexity of processing pathological material, as well as the need to use expensive culture media for inoculation for culture research; – low reliability of the Mantoux reaction and the Rabukhin test; – high cost of research, a large number of false positive results due to both technical difficulties and the peculiarities of the PCR method (polymerase chain reaction); – exposure to ionizing radiation, the impossibility of using for the diagnosis of extrapulmonary forms of tuberculosis, the high cost of consumables for fluorographic examination; – low sensitivity (detection of mycobacterium tuberculosis with a content of at least 1000 microbial bodies in 1 ml of material) with a bacterioscopic method, etc.