The first experience in the treatment and prevention of complications of diabetes mellitus in children

AUTHORS : Abaeva L.F. | Petritskaya E.N. | Ivanova I.E. | Remarchuk G.V. | Gotovsky M.Yu.

RELEVANT UNIVERSITIES : MONIKI named after M.F. Vladimirsky, Center “IMEDIS”, Moscow, Russia

YEAR : 2005 | Category : Experience

Diabetes mellitus (DM) is one of the pressing health problems. This is a complex polyetiological disease in which all types of metabolism are disrupted. From 3 to 8% of the population of economically developed countries are sick with diabetes mellitus. Often, the development of insulin-dependent diabetes mellitus is preceded by viral infections (rubella, mumps, chickenpox, herpes, hepatitis, mononucleosis), vaccinations, and opisthorchiasis.

In response to a viral infection, insulitis (inflammation of beta cells) appears with the infiltration of pancreas tissue with lymphocytes. Immune tolerance breaks down, retoxins are formed, retoxic impregnation occurs with a transition to the degeneration phase (Biological medicine, No. 2, p. 55, 1998). The immunological scheme for the development of diabetes corresponds to the phases of homotoxicosis H.H. Reckeweg through the reaction stage and the inflammation stage.

According to modern concepts, insulin-dependent diabetes mellitus (IDDM) develops as a result of the destruction of beta cells of the islets of the pancreas, which has autoimmune failure. With every autoimmunity and production nature and the th injection of insulin stimulates antibodies not only to the injected, but also to the endogenous ending development insulin insulin. This largely explains the complexity of IDDM therapy.