Possibilities of the BRT method in the treatment of chronic diabetic distal sensorimotor polyneuropathy in elderly patients
AUTHORS : Zubarkin MM. | Millstone V.A.
RELEVANT UNIVERSITIES : Peoples’ Friendship University of Russia, Moscow, Russia
YEAR : 2013
Diabetic neuropathy is a dysfunction of the somatic and / or autonomic peripheral nervous system, caused by the actual diabetic pathophysiological and dysmetabolic processes [16]. The incidence of diabetic neuropathy, according to various authors, varies from 40 to 95% of all
cases of diabetes mellitus (DM) [9]. The pathogenetic basis of the formation of the syndrome of diabetic neuropathy is oxidative stress, which develops as a result of the formation of a large
number of free radicals against the background of insufficiency of its own antioxidant systems, due to the activation of the thiol pathway of glucose metabolism, an increase in the activity of protein kinase C, the formation and accumulation of end products of non-enzymatic interaction
of glucose with proteins, nucleotides and lipids (advanced glycation end products, AGEs),
