Diagnostics and therapy of adrenogenital syndrome in obstetric gynecological and general therapeutic practice
AUTHORS : Bobrov I.A. | Pechnikova E.Yu.
RELEVANT UNIVERSITIES : Clinic “Family +”, Moscow, Russia
YEAR : 2007
Adrenogenital syndrome (AGS) is a collective term that includes clinical symptoms associated with impaired secretion of corticosteroids due to a
congenital defect in enzymes. As a result of such a violation, glucocorticoid insufficiency develops, and, as a consequence, an increase in ACTH synthesis,
causing an increase in androgen levels, accompanied by adrenal hyperplasia, and inhibition of aldosterone function [1, 2].
The presence of this group of diseases is due to the lack of a number of enzymes. The most common deficiencies are 21-hydroxylase (95% of all cases of
adrenal hyperplasia) and 11-hydroxylase. The location of the gene encoding 21- hydroxylase is also known, namely, in close proximity to the genes encoding HLA-B
and HLA-DR, on the short arm of chromosome 6.
